Imidazo[1,2-a]pyridine,Imidazo[1,2-a]pyrimidine and Imidazo[1,2-a]pyrazine are important building blocks, used in medicinal chemistry.

Synthesis of Imidazo[1,2-a]pyridine.




To a solution of the appropriately substituted 2-aminopyridine (0.08 mole) in 95% ethanol or dioxane (30-50 mL),was added an equimolar amount of the required a-halo ketone or a-haloaldehyde . After the addition of 2 mole equiv. of NaHCO3, the stirred mixture was refluxed for 14-22 hr. The dark brown reaction mixture was then filtered and the filtrate was made basic (pH 10) with 5% aqueous NaOH. The aqueous solution was extracted with three 100 mL portions of CHCl3 and the combined extracts were dried (anhydrous Na2CO3) and filtered. The CHCl3 was then removed in vacuo and the residual oil was vacuum distilled to yield the substituted imidazo[l,2-a]pyridine.




2-amino pyrimidine (0.5 mol) was dissolved in 50% hydro-alcoholic solution in presence of sodium hydrogenocarbonate (0.6 mol). To this mixture, a water solution (40%) of chloroacetaldehyde (1 mol) was added slowly under nitrogen with vigorous stirring and was refluxed for 48 h. After this period, the reaction mixture was cooled, concentration in vacua, poured into water and extracted with hot chloroform. The organic layer was dried (MgSO4) and evauorated in vacuo. Pure imidazo[1.2-a]pyrimidine was obtained after chromatography on a silica gel column (eluent :ethylacetate).




A solution of 2.85 g (30.0 mmol) of aminopyrazine in 100 mL of CH2Cl2 was added to 28.5 g alumina . The resulting stirred suspension was treated with a solution of 2,3-epoxypropanal (cis and trans; 2.58 g, 30.0 mmol) in 10 mL of CH2Cl2 and the suspension was stirred overnight at room temperature under N2. The mixture was vacuum filtered, and the cake was washed with 100 mL of CH2Cl2 and two, 100-mL portions of 2% MeOH-CH2Cl2. The combined filtrate was concentrated under vacuum at 25 oC to give 3.6 g of orange solid, which was chromatographed on activity III alumina. Elution with CHzCl2 gave fractions containing 1.25 g of pure 3-(l-hydroxyethyl)- imidazo[l,2-a]pyrazine (26%).

The application of Imidazo[1,2-a]pyridine.

Hot products of this month

(CAS# 24214-72-0)
1-cyclopentylhydrazine hydrochloride
Availability: Over 1kg
Mini package: 5g

(CAS# 16726-41-3)
1-isopropylhydrazine hydrochloride
Availability: Over 1kg
Mini package: 5g

(CAS# 24214-73-1)
1-cyclohexylhydrazine hydrochloride
Availability: Over 10kg
Mini package: 5g

(CAS# 59718-84-2)
methyl 3-methylpicolinate
Availability: Over 500g
Mini package: 5g

(CAS# 64321-24-0)
Availability: Over 500g
Mini package: 5g

(CAS# 914358-73-9)
Availability: Over 500g
Mini package: 5g

(CAS# 1150617-80-3)
Availability: Over 100g
Mini package: 1g

(CAS# 91420-25-6)
Availability: Over 250g
Mini package: 5g >

We deliver an innovative chemical database for your commercial sourcing.


Over 25 kilo chemicals are available here for commercial sourcing.

Enquiry can be placed on-line at or, by mailing to or, and fax to +86 21 52685809.

We receive the order sent via the Email and fax and the payment by PAYPAL, credit card and T/T.


Search for the product by structure at

Search the CofA of the product online at HOMEPAGE of

Search MSDS on the right side of the general information of every product

Check the updated status of your order at

Download our product list at


The standardization laboratory of IS Chemical Technology in Jinshan District, Shanghai City, will provide the quality assurance for you. Before delivery, all products pass through the structure identification and assay checking, and are attached with COA, NMR report and MSDS.


IS Chemical Technology commits to make every effort to ensure the delivery on schedule.

We use air express, such as FedEx, DHL and EMS, for most packages, and rate varies depend on location, package weight, and shipping type etc.

International Shipping charge,

$45-55/per package (quantity: <0.5kg);

POA for quantities over 0.5 kg


IS Chemical Technology pays more attention to the business credit and has been devoting to establish sincere and faithful business relation with the partners. In 2009, IS Chemical Technology took the lead in cooperating with Dun & Bradstreet, the world leading credit management and consulting agency, participating in the D&B D-U-N-S Registered program of the company.